Kratom: Technical Alkaloid Profile & Protocols

Mitragyna Speciosa, commonly known as Kratom, is a complex botanical with a diverse pharmacological profile. Understanding the specific alkaloids and their dosage-dependent effects is critical for safe and effective biohacking.

1. Mitragynine (MG): The Primary Stimulant

Mitragynine makes up approximately 66% of the total alkaloid content in the leaf. At low doses (1-5g), it acts as an adrenergic agonist, increasing focus, physical energy, and mental clarity. It binds to mu-opioid receptors but acts as a G-protein biased agonist, which significantly lowers the risk of respiratory depression compared to traditional opioids.

2. 7-Hydroxymitragynine (7-OH): The Primary Analgesic

While 7-OH is a minor constituent (<2% in raw leaf), it is 13-46x more potent than morphine. It is primarily responsible for the sedative and analgesic modes at high doses (5-15g). It is important to note that semi-synthetic extracts high in 7-OH carry a much higher risk for physical dependence and should be used with extreme caution.

3. The Biohacking Protocols

• The "Focus" Mode: 1g to 2g of White or Green vein. Ideal for cognitive enhancement and sustained attention.
• The "Recovery" Mode: 4g to 6g of Red vein. Used for physical recovery and down-regulating the nervous system after intense exertion.