Kratom: Science and Alkaloids

Kratom: The Alkaloid Profile of Mitragyna Speciosa

Kratom is a Southeast Asian botanical that has been used for generations as both a stimulant and a recovery aid. Its effects are primarily driven by two key alkaloids: Mitragynine and 7-Hydroxymitragynine.

Mitragynine: The Focus Driver

Making up approximately 66% of the total alkaloid content, Mitragynine acts as a stimulant at low doses. It binds to mu-opioid receptors but operates as a G-protein biased agonist, which significantly reduces the risk of respiratory depression compared to traditional opioids.

7-Hydroxymitragynine: The Recovery Component

While only a minor constituent (<2%) in raw leaf, 7-OH is significantly more potent and is responsible for the analgesic and sedative effects found at higher dosages. It is essential to use high-quality, lab-tested leaf to ensure a safe alkaloid balance.