Apigenin Anxiolytic Pathway

THE MECHANICS

DMT administration can be carried out through inhalation, oral ingestion, or intravenous injection. Inhalation involves vaporizing or smoking DMT-rich plant material, resulting in rapid onset (1-2 minutes) and short duration (30-45 minutes). Oral ingestion includes consuming ayahuasca, which contains both DMT and MAOIs like harmala alkaloids from Banisteriopsis caapi, leading to slower onset (30-60 minutes) but longer duration (2-4 hours). Intravenous injection results in rapid onset (seconds) but shorter duration (15-20 minutes).

THE BIOLOGICAL LEVERAGE

The LDS induction protocol involves taking 4-8mg of Galantamine orally at least an hour before DMT ingestion, enhancing the intensity and duration of the experience. DMT binds to serotonin receptors, particularly 5-HT2A, and trace amine-associated receptors (TAARs), specifically TAAR-1. It increases serotonin levels in the brain, leading to changes in perception, cognition, and mood. Activation of 5-HT2A receptors triggers second messenger systems such as cAMP/PKA, leading to CREB activation, which facilitates gene transcription activity within neurons.

THE TACTICAL IMPLEMENTATION

In long-term potentiation, CREB is activated by both Ras/ERK pathway and the cAMP/PKA pathway. Compounds like PQQ (Pyrroloquinoline Quinone) and Pterostilbene can help boost CREB activity, while inhibitors of phosphodiesterase 4 (PDE4), such as Resveratrol, Oat Straw, and Artichoke Extract, prolong the activation of cAMP via PKA, enhancing CREB-mediated gene transcription. Indolethylamine N-Methyltransferase (INMT) catalyzes the methylation of biogenic amines to produce DMT. This enzyme is present in various tissues including the brain and lungs, with lung tissue exhibiting the highest levels of expression.

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